Before I read On the Road I already knew about its cultural significance. In its day, this short novel shocked society with its explicit sex and drug use. Reading it today it does not feel that offensive. However, realizing that most of this semi-autobiographical tale takes place around 1947-48 is quite amazing to me. This feels like 1968, not 1948, so I can see what it was influential for its time.
The story is told from the point of view of Salvatore "Sal" Paradise, who is filling the autobiographical role of Jack Keruoac. The other main character is the free-spirited, reckless (and slightly bi-polar) Dean Moriarty, who Keruoac based on his friend Neal Casssady. A large cast of other characters interact with Sal and Dean as they travel back and forth across the country from New York, Chicago, Denver, Texas and California.
Dean Moriarty is the quintessential care-free spirit who loves to "dig" life, people and places. However, he cannot hold any long-term commitments to his girlfriends, wives, children or friends. In fact, at the end of the novel he eventually even abondons his travel companion Sal who has fallen ill in Mexico with dysentery. Sal seems enthralled by Dean, since even he cannot resist his overwhelming energy and enthusiasm for life - although he feels himself reluctantly carried on by Dean's impulsive, frenetic activities.